The efficiency of PAF inhibitors and especially PAF-R antagonists to protect against atherosclerosis development was firstly documented with the administration of BN 52021 (ginkgolide B) at a dose of 20 mg/kg in rabbits fed with a cholesterol-enriched diet [89] and has also been reported with the fraction of polar glyco-lipids isolated from fish, leading to lower PAF levels and its activity in the blood of rabbits, by down-regulating PAF biosynthesis and up-regulating PAF catabolism [90]. This evidence concerns the gene PCLAF and atherosclerosis.