EZR and esophageal squamous cell carcinoma: On the other hand, EZR-AS1 recruits SMYD3 (lysine methyltransferase) and binds it to the GC-rich SBS-1 site downstream of the EZR promoter, resulting in H3K4 methylation in the EZR promoter region, leading to upregulation of EZR transcription in oesophageal squamous cell carcinoma (ESCC) cells [33].