Serum concentrations of adipokines, leptin, adiponectin, visfatin and resistin and inflammatory markers associated with low-grade inflammation in obesity, CRP, IL-6, sE-selectin, sVCAM, sPECAM and VEGF, were similar in both groups, regardless of CK-18. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.