(2017) of 12 studies, the plasma concentration of FGF-21 in NAFLD was significantly higher than that in a control group, and the diagnostic odds ratio, sensitivity and specificity of FGF-21 testing for NASH were 5.70, 0.62 and 0.78, respectively [41]. This evidence concerns the gene FGF21 and metabolic dysfunction-associated steatohepatitis.