Serum concentrations of adipokines, leptin, adiponectin, visfatin and resistin and inflammatory markers associated with low-grade inflammation in obesity, CRP, IL-6, sE-selectin, sVCAM, sPECAM and VEGF, were similar in both groups, regardless of CK-18. The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.