Indeed, the levels of P-LPE in mouse skin are correlated well with the expression levels of sPLA2-IIF in multiple skin disease models, and topical application of P-LPE to Pla2g2f−/− skin in vivo or supplementation of Pla2g2f−/− keratinocytes with P-LPE ex vivo restores the psoriasis-related phenotypes [65]. The gene discussed is PLA2G2F; the disease is psoriasis.