While sPLA2-IB is secreted from the pancreas into the intestinal lumen and acts as a digestive enzyme [3], sPLA2-IIA, initially identified in the synovial fluid of arthritis patients and in platelets, is the only sPLA2 that is abundantly detected in the circulation of patients with inflammation or infection and has been considered to participate in systemic or local inflammation and antibacterial defense [4]. Here, PLA2G2A is linked to Arthritis.