AD is a progressive brain disease characterized by changes in the brain, including amyloid plaques formed by β-amyloid protein deposition, neurofibrillary tangles formed by the hyper-phosphorylation of tau proteins, and neuronal loss caused by glial cell proliferation, resulting in the loss of neurons and their connections exhibited as memory loss and progressive cognitive impairment in patients [44]. The gene discussed is MAPT; the disease is Alzheimer disease.