STUB1 and Alzheimer disease: For example, Tang et al. reported that lysine demethylase 1A (KDM1A) overexpression increased the expression of METTL3 in AD, which then stabilized STUB1 mRNA through the m6A-IGF2BP1-dependent mechanism to enhance STUB1 expression, thereby enhancing autophagic p-Tau clearance in Aβ1-42-treated cells [49].