METTL3 and glioma: For example, in the blood–tumor barrier (BTB) model constructed by glioma microvascular endothelial cells (GECs), Zhang et al. reported that upregulation of METTL3 and IGF2BP3 increased the stability of CPEB2 mRNA through its m6A methylation [56], while CPEB2, in turn, binds to and increases the stability of the SRSF5 mRNA, promoting the inclusion of ETS1 exons [56].