METTL3 and central nervous system cancer: Moreover, Shi et al. reported that the METTL3 knockdown increased the self-renew, proliferation, and temozolomide (TMZ) half-maximal inhibitory concentration of glioma stem cells (GSCs) via reducing METTL3-mediated m6A modification of DNA repair gene (MGMT and APNG) mRNAs that subsequently inhibited TMZ sensitivity of GSCs [57].