METTL3 and Alzheimer disease: The study from analyzing the brain of AD patients and Aβ-induced cell models indicated that METTL3 was downregulated to inhibit ARC expression via YTHDF1-dependent m6A modification, which then impaired the synaptic plasticity to influence memory capacity, while overexpression of METTL3 rescued ARC expression after Aβ treatment [24].