BDNF and schizophrenia: In a human study of cohorts of schizophrenia patients in the United States and Australia, Wong et al. [21] found that the transcripts of both BDNF-e2 and -e6 were significantly reduced in the parietal cortex, BDNF-e2 transcripts were reduced in the dorsal lateral prefrontal cortex (DLPFC), and BDNF-e6 transcripts were decreased in the hippocampus of schizophrenia patients compared with healthy controls.