BDNF and schizophrenia: They found that a deficiency in the Promoter VI-driven expression of Bdnf combined with adversity early in life gave rise to schizophrenia-like behaviors, such as deficits in social interactions, spatial memory, and sensorimotor gating, as measured by the pre-pulse inhibition test (PPI) [11], indicating a direct relationship between Bdnf Promoter VI and the risk of developing schizophrenia-like behavior, at least in rodents.