TP53 and type 2 diabetes mellitus: It has also been demonstrated that during the diabetes onset in both STZ-induced T1D and db/db of type 2 diabetes (T2D) mouse models, the p53 protein increases in the β cells, which leads to the inhibition of mitophagy through the PINK1/PERKIN pathway, which results in β cell mass reduction, especially in T2D [40].