This study described the infiltration of activated (CD45+CD11b+Ly6C−MHCII+F480+) and pro-inflammatory M1 (CD45+CD11b+Ly6C−MHCII+F480+CD206−) macrophages, along with upregulation of inflammatory pathways, in the hearts of DCM animals. The gene discussed is PTPRC; the disease is familial dilated cardiomyopathy.