CHI3L1 and chronic kidney disease: In addition, in the Chronic Renal Insufficiency Cohort (CRIC) Study, which involved 894 patients, high plasma levels of KIM-1, TNFR-1, TNFR-2, MCP-1, suPAR, and YKL-40 were associated with an increased risk of DKD progression, with TNFR-1 being discussed in further detail in another section [60].