Other targets included the glucose transporter family (GLUT1, GLUT2, GLUT3 and GLUT4), critically important for host immunity [38,39]; and some components in the insulin signaling pathway, including insulin receptor (INSR) and protein kinases AKT1, GSK3β and PIK3R1, which are shown to be important in insulin resistance in macrophages [26,40] (Figure 1). Here, INSR is linked to Insulin resistance.