Distinguishing tumor tissue from benign surrounding tissues using an imaging technique that is easy to use, such as NIR fluorescence imaging, is one of the key elements to improve the quality of pancreatic surgery [6] of the most commonly targeted and studied biomarkers for pancreatic cancer is the carcinoembryonic antigen (CEA), which is a glycoprotein involved in cell adhesion and is overexpressed in more than 90% of pancreatic cancers [7,8,9]. The gene discussed is CEACAM5; the disease is neoplasm.