AGT and triple-A syndrome: Dietary supplementation of Celastrol significantly promoted a low dose of AngII-induced abdominal aortic luminal dilation (Figure 2A,B) and external aortic width (Figure 2C,D) in male mice as measured by ultrasonography and ex vivo measurement, with 90% AAA incidence (10/11) compared to 36% (4/11) in the control group (Figure 2E).