Since female mice are highly resistant to AngII-induced AAA formation, in this study, female Ldl receptor -/- mice were infused with either saline or a high dose of AngII (1000 ng/kg/min) for 4 weeks and fed HFD with or without Celastrol for 5 weeks starting one week before AngII infusion. This evidence concerns the gene AGT and triple-A syndrome.