AGT and triple-A syndrome: Based on the observed early acceleration of AngII-induced aortic dilation at week 2 with Celastrol supplementation and given that AngII promotes AAA severity and incidence in a dose-dependent manner, in the next step, we tested the effect of Celastrol supplementation with a low dose of AngII (500 ng/kg/min) to examine if there is any effect of Celastrol supplementation on the acceleration of a low dose of AngII-induced AAA formation in hypercholesterolemic mice.