Synergistic photothermal therapy (PTT), photodynamic therapy (PDT), or radiofrequency ablation (RFA) with HSP70 inhibitors, a combination treatment which has already shown improved efficiency than PTT, PDT, or RFA used alone in liver cancer, breast cancer, cervical cancer, and pancreatic cancer, offers an immediate translational potential in the management of numerous cancers [179,180,181,182,183]. Here, HSPA1A is linked to breast cancer.