S1g-6, an HSP70 inhibitor, plus Bcl-2/Mcl-1/Bcl-xl triple inhibitor S1 or FDA approved Bcl-2 inhibitor ABT-199 showed synergistic effect with S1g-6 in inducing tumor regression by inducing apoptosis in leukemia cells [160]. The gene discussed is BCL2; the disease is leukemia.