When arrived at tumor cells, the cPt ZIF skeletons were nanomotors collapsed with the chemotherapeutic cPt drug and cargoes being released in response to the overexpressed intratumoral acid species (pH 6.5–6.9) and reductive GSH (Scheme 1B).[35] In this stage, overproduced intratumoral H2O2 was decomposed by CAT to generate O2, which was developed for O2‐dependent PDT therapy.[36] Meanwhile, intracellular H2O2 can be continuously supplied by GOx‐catalyzed consumption of glucose with gluconic acid as by‐product. The gene discussed is CAT; the disease is neoplasm.