They found higher endocan concentrations in diabetic patients with subclinical atherosclerosis (1.20 ± 0.33 ng/ml) compared to diabetic patients without subclinical atherosclerosis (0.89 ± 0.28 ng/ml, p-value < 0.05) and healthy controls (0.68 ± 0.24 ng/ml). The gene discussed is ESM1; the disease is atherosclerosis.