Notably, IMP4’s mRNA expression is significantly lower in Alzheimer’s disease (AD) patients as compared to controls in both temporal cortex (P = 0.003) and prefrontal cortex (P = 2.6 × 10−6), the two most relevant brain regions for AD pathogenesis (Additional file 1: Fig. S5) [41–43]. The gene discussed is IMP4; the disease is Alzheimer disease.