Notably, IMP4’s mRNA expression is significantly lower in Alzheimer’s disease (AD) patients as compared to controls in both temporal cortex (P = 0.003) and prefrontal cortex (P = 2.6 × 10−6), the two most relevant brain regions for AD pathogenesis (Additional file 1: Fig. S5) [41–43]. Here, IMP4 is linked to early-onset autosomal dominant Alzheimer disease.