In acute myocardial infarction (AMI), miR-379 binds tumor necrosis factor-α-induced protein 8 (TNFAIP8) and inhibits its activity significantly, leading to the reduce of the level of apoptosis and the inhibition NK-κB signal pathway in H9c2 cells. The gene discussed is TNFAIP8; the disease is acute myocardial infarction.