Yixiang Huang et al. found that in breast cancer, circular RNA circRPPH1 acted as a miRNA sponge of miR-512-5p, which inhibits the combination of miR-512-5p and 3 '- UTR of STAT1, reduces the expression of STAT1, and promotes the he proliferation, migration and colony formation ability of Breast cancer cells [42].miR-668 plays a protective role against renal injury after ischemia–reperfusion (IRI). Here, STAT1 is linked to breast cancer.