RNASE1 and endothelial dysfunction: To understand how bEVs influence sepsis progression and endothelial dysfunction, we investigated the impact of bEVs from the sepsis-associated pathogens Escherichia coli, Klebsiella pneumoniae, Salmonella enterica serovar Typhimurium and Streptococcus pneumoniae on RNase1, a vessel protective factor, in human lung ECs.