Regarding the 1-year mortality in patients with AIS, RPR was associated with 1-year mortality in AIS patients with age < 65 years old (HR: 2.54, 95% CI: 1.56 to 4.14, P < 0.001), age ≥ 65 years old (HR: 1.38, 95% CI: 1.06 to 1.19, P = 0.015), in AIS patients with (HR: 1.46, 95% CI: 1.15 to 1.85, P = 0.002) and without using IV-tPA (HR: 2.30, 95% CI: 1.03 to 5.11, P = 0.041), in AIS patients without using endovascular treatment (HR: 1.56, 95% CI: 1.23 to 1.96, P < 0.001), and in AIS patients without myocardial infarction (HR: 1.68, 95% CI: 1.31 to 2.15, P < 0.001). The gene discussed is PLAT; the disease is myocardial infarction.