Regarding the outcome of 30-day mortality, RPR was associated with 30-day mortality in AIS patients aged < 65 years (HR: 2.19, 95% CI: 1.17 to 4.10, P = 0.014), in AIS patients without using IV-tPA (HR: 1.42, 95% CI: 1.05 to 1.90, P = 0.021), in AIS patients without using endovascular treatment (HR: 1.45, 95% CI: 1.08 to 1.94, P = 0.012), and in AIS patients without myocardial infarction (HR: 1.54, 95% CI: 1.13 to 2.10, P = 0.006). The gene discussed is PLAT; the disease is myocardial infarction.