CDH1 and metastatic neoplasm: Since the E-cad protein is postulated to play a critical role during the transition from primary tumors to metastatic tumors in carcinomas [12, 13, 28, 53, 54], we assessed how the E-cad levels differed in the cell lines derived from metastatic tumors compared to those derived from primary tumors using the proteomics data on the CCLE available in the DepMap portal.