Consistent with the lower levels of CDH1 mRNAs in kidney carcinoma (Fig. 7A-C), analysis using the UALCAN web server revealed that the levels of E-cad protein in kidney cancer were significantly downregulated in tumors compared to normal tissue (Fig. 4C) and E-cad was not detectable in the immunohistochemistry staining of kidney carcinoma (Fig. 5D), demonstrating that the lower levels of CDH1 mRNA result in lower levels of E-cad protein [37]. The gene discussed is CDH1; the disease is kidney cancer.