CDH1 and neoplasm: To prevent anoikis induced by truncation of the cytoplasmic domain of E-cad which results in disruption of the binding of the domain to β-catenin, a linker protein that connects the actin cytoskeleton to the cytoplasmic domain of E-cad [74, 75], tumor cells may be required to upregulate E-cad [76, 77].