For the patients with carcinomas that had downregulated CDH1 mRNA, including kidney cancer (Fig. 1C), CDH1 mRNA expression had a significant effect on OS but not DFS (High, n = 258 vs Low, n = 258; p = 3.7E-06 and 0.11, respectively) (Fig. 8D-E). This evidence concerns the gene CDH1 and carcinoma.