In agreement with recent debates on the role of E-cad in tumor progression and metastasis [63, 64], our analysis demonstrates that CDH1 mRNA and E-cad protein are not downregulated in the majority of carcinomas (Figs. 1, 4, and 5) or during tumor progression in most carcinomas (Figs. 2 and 4E, and Supplementary Figs. 1 and 2—Additional file 1). This evidence concerns the gene CDH1 and carcinoma.