CDH1 and renal carcinoma: When kidney carcinoma was divided into four subtypes based on the differential expression of 500 genes and 500 microRNAs [61], CDH1 mRNA levels were significantly downregulated in cluster 2 (m2), cluster 3 (m3), and cluster 4 (m4), but remained unchanged in cluster 1 (m1) compared to normal tissues (Fig. 7A).