SPOCK2 belongs to a group of SPARC proteins, which encompasses various proteins that have been studied in various gastrointestinal malignancies, such as biliary tract cancers (BTC) (Aghamaliyev et al. 2019), PDAC (Vaz et al. 2015), and colon cancer (Zhong et al. 2019). Here, SPOCK2 is linked to colonic neoplasm.