To attempt to correlate the phenotypes of RELN-COLBOS in mice and humans, we used a crossbreeding strategy, using our knockin mouse model and a tauopathy mouse model, specifically the STOCK Tg(Prnp-MAPT*P301L)JNPL3Hlmc mouse from the Hutton’s laboratory, distributed by Taconic Biosciences. The gene discussed is PRNP; the disease is tauopathy.