PSEN1 and dementia: However, he had relatively limited Tau pathology in the entorhinal cortex (ERC) (SUVR = 1.34; Fig. 1a,c) and in other neocortical regions, such as the posterior cingulate cortex (PCC) and precuneus (SUVR PCC = 1.51; SUVR precuneus = 1.49; Fig. 1a), which usually show greater levels of Tau pathology in PSEN1-E280A carriers who develop MCI and dementia at a typical age3 (Fig. 1, Supplementary Fig. 2 and Extended Data Figs. 1 and 2).