The cases with RELN-COLBOS and APOECh showed distinctively lower intraneuronal APOE signal than the controls with familial and sporadic AD (Fig. 5d and Supplementary Table 10) whereas the case with RELN-COLBOS showed higher Reelin intracellular signal in the white matter (Fig. 5e and Extended Data Fig. 10). The gene discussed is APOE; the disease is Alzheimer disease.