Finally, we performed pathway enrichment analysis (see ‘Methods’) on the DE signatures derived from the RNAseq data in order to identify the unique and shared pathways affected by the knockdown of the 10 AD endophenotype-modulating targets (JMJD6, NSF, NUDT2, DCAF12, RBM4, YWHAZ, NDRG4, STXBP1, FIBP and ATP1B1). Here, YWHAZ is linked to Alzheimer disease.