PLCB3 and Alzheimer disease: Moreover, we found certain common genes affected by the perturbation of multiple validated targets: 6 genes (FGF11, GIT2, KLHL28, PLCB3, SEPSECS, and SLC48A1) were affected by knockdown of NDRG4, STXBP1, YWHAZ, and JMJD6, and 9 genes (SEPTIN3, ABR, AOC2, CTFIP2, ZGTF2H1, MRPL17, NIIPSNAP1, RIMS4, and TMEM246) were affected by perturbation of DCAF12, NSF, and NUDT2. This observation indicates that there may be unique and common molecular pathways among these validated AD endophenotype-modulating targets; we illustrate the significant overlap of DE genes after each target knockdown in Fig. 6l.