Of note, however, 5 of these 11 placental genes (CLP1, MARK3, KLC1, TRMT61A, APOPT1) were associated with opposite sign between the two disorders, suggesting that both an up-regulation and a down-regulation in placenta of these genes may bias towards neurodevelopmental trajectories of risk for psychiatric disorders (Supplementary Data 46, 54). This evidence concerns the gene CLP1 and psychiatric disorder.