Moreover, this line of research may help to identify strategies of postnatal prevention benefiting subjects at higher risk, given that alterations of the placental risk genes can be detected decades before the possible onset of the disorder, i.e., at birth, when the placenta is available86, or even during pregnancy, detecting placenta-derived molecules in maternal blood;87 in this regard, the placental TWAS schizophrenia genes ZNF664 (prioritized), KLC1, MAN2A2, CTDSPL, and MSI2 have been detected in maternal blood as cell-free RNAs potential useful for the prediction of pregnancy outcomes87. This evidence concerns the gene MAN2A2 and schizophrenia.