Thus, the WGCNA analysis indicated that some placental schizophrenia risk genes may converge on biological processes and etiopathogenetic mechanisms, common to the two sexes (mTOR signaling), albeit not necessarily driven by the same genes; at the same time, other placental schizophrenia risk genes may converge on sex-specific processes (insulin signaling in females, and IL15 signaling in males) revealing a possible impact of the sex-biased architecture on placental gene coexpression (see Supplementary Data 28 for further details). This evidence concerns the gene INS and schizophrenia.