UQCC3 and schizophrenia: The upstream regulators enriched for the placental schizophrenia risk genes included UQCC3, a mitochondrial factor with a crucial role in bioenergetic reprogramming linked with hypoxia47, serotonin—known to mediate the effect of maternal inflammation on offspring neurodevelopment48—, and PCB5349 (also known as 2,4,5,2′,4′,5′-hexachlorobiphenyl), a chemical suspected to alter brain development (Fig. 1d; Supplementary Data 13).