LAIR1 and neoplasm: In the present study, the mechanism of how ECM educates the observed macrophage phenotype seen has not been investigated, however, transcriptomic data points to two potential mechanisms, both receptor-ECM interactions: there is leukocyte-associated Ig-like receptor 1 (LAIR1) which may signal immunosuppressive gene programs when activated through collagen binding59, or sialoglycan-siglec signaling60 where sialoglycans upregulated within tumor tissue may be ligands for immune-inhibitory siglecs on infiltrating macrophages.