Markedly, this occurred with a parallel increase in HIF-1α target genes Hexokinase 2 (HK2), glucose transport 1 (Glut1), Monocarboxylate transport 4 (MCT4) in NSCLC H1299 and A549 cells, but not in H446 and H1688 cells (Fig. 2C). Here, HK2 is linked to non-small cell lung carcinoma.