NEDD4L and non-small cell lung carcinoma: Taken together, we propose a new drug resistance model in NSCLC cells, where etoposide induces cell metabolic reprogramming, leading to the accumulation of lactic acid in the microenvironment; Lactic acid inhibits GPX4 ubiquitination and promotes GPX4 accumulation by inactivating the E3 ubiquitin ligase NEDD4L, resulting in ferroptosis resistance in NSCLC.