The genomic regions flanking the 671 subcutaneous sentinels were enriched for 7 distinct TF binding motifs (P range 1 × 10–9 to 1 × 10–13); 5 motifs at hypo- (lower in obesity) and 2 motifs at hyper-methylated (higher in obesity) sentinels (median 28 range 16-86 sentinels per motif, Fig. 3a, Supplementary Data 16). This evidence concerns the gene TF and obesity due to melanocortin 4 receptor deficiency.