ATG5 and hepatocellular carcinoma: In HCC and primary liver cells overexpressing ANGPTL8, the presence of FR180204 increased the amount of LC3II/I and decreased the amount of ATG5 and Beclin-1 (Figs. 4A–D and S8), and FR180204 reduced the number of autophagosomes induced by rANGPTL8 (Figs. S9 and 4E, F).