It is now evident that ANGPTL8 contributes to inflammatory diseases [11, 12], our previous research determined that ANGPTL8 is a proinflammatory cytokine secreted by hepatocytes into the liver microenvironment to regulate hepatic stellate cell activation, which in turn accelerates nonalcoholic fatty liver disease (NAFLD)-associated liver fibrogenesis [13]. This evidence concerns the gene ANGPTL8 and metabolic dysfunction-associated steatotic liver disease.