Finally, as a highly expressed secretory protein in HCC cells, mechanistic studies to determine how ANGPTL8 precisely regulates interactions between HCC cells and other cells in the tumor immune microenvironment and whether it coincides with the site of LILRB2/PIRB binding when ANGPTL8 interacts with hepatocytes and Kupffer cells are important questions to be answered in future studies. Here, ANGPTL8 is linked to neoplasm.