ANGPTL8 and cholangiocarcinoma: Although the expression and prognostic potential of ANGPTL8 in different cancers have been analyzed [8], these studies have primarily considered tumor molecular profiling data for their conclusions, and a few reports suggest that ANGPTL8 could promote the progression of renal cell carcinoma [9], but inhibit the development of breast invasive carcinoma and cholangiocarcinoma [10].