ANGPTL8 and hepatocellular carcinoma: To explore the effect of ANGPTL8 on the proliferation of HCC cells in vitro and on tumorigenic capacity in vivo, we engineered MHCC97H and HepG2 HCC cells as well as LO2 normal liver cells with lentivirus-mediated CRISPR-Cas9 or with an ANGPTL8 OE vector.