Second, ANGPTL8 could also interact with PIRB in macrophages (Kupffer cells) to upregulate Fgr expression and drive macrophage polarization into the M2 phenotype to suppress anti-tumor immune responses by increasing the number of CD4+FOXP3+ and CD8+PD-1+ T cells in the tumor microenvironment. This evidence concerns the gene ANGPTL8 and neoplasm.