ANGPTL8 and neoplasm: Tumor development was monitored by ultrasound imaging, which revealed that the livers of WT mice had uneven edges, abnormal parenchymal morphology, and space-occupying lesions, whereas the livers of ANGPTL8-KO mice had a uniform texture, normal size and shape, no obvious ascites or peripheral lymphatic enlargement, and no obvious space-occupying lesions (Fig. 1F).