Immunofluorescence analysis of DEN-induced mouse HCC tumors using T-cell markers also determined that the number of infiltrating immunosuppressive CD4+FOXP3+ and CD8+PD-1+ T cells was significantly reduced in ANGPTL8-KO tumors compared to WT tumors (Fig. S16). The gene discussed is ANGPTL8; the disease is hepatocellular carcinoma.