INS and type 2 diabetes mellitus: The T allele carriers had a higher incidence of T2DM (Figure 1G, CC homozygote: 36.38%; T allele carriers: 49.07%), glucose intolerance (Figure 1H; Supplementary Figure S1I), and insulin resistance (Supplementary Figure S1L), while plasma insulin levels during OGTTs were unaffected (Supplementary Figure S1J and K).