After screening genetic variants of the human gene BRSK2, we identified three variants associated with diabetes mellitus and related glucose metabolic traits, including rs112377266 (Figure 1A–D, −>dup(G)4CTCACCTGTGG, an insertion variant in intron 15 of the BRSK2 gene, minor allele frequency = 0.37), rs61002819 (Figure 1E and F, G>−, a deletion variant in the splice region, variant frequency = 0.11), and rs536028004 (Figure 1G and H, C>T, a 3′-untranslated region (3′-UTR) variant, variant frequency = 0.01). This evidence concerns the gene BRSK2 and diabetes mellitus.