BRSK2 variant carriers may exhibit congenital hyperinsulinism due to β-cell hypersecretion, which causes a vicious cycle between hyperinsulinemia and insulin resistance, akin to the most recognized genetic variants of ABCC8 and KCNJ11 in T2DM (De Franco et al., 2020). The gene discussed is KCNJ11; the disease is Insulin resistance.