BRSK2 variant carriers may exhibit congenital hyperinsulinism due to β-cell hypersecretion, which causes a vicious cycle between hyperinsulinemia and insulin resistance, akin to the most recognized genetic variants of ABCC8 and KCNJ11 in T2DM (De Franco et al., 2020). Here, KCNJ11 is linked to type 2 diabetes mellitus.