In terms of tumor regulation, EGR1 promotes tumor progression by improving the growth and reproduction ability, as well as migration and invasion ability, of cancer cells in some tumors, but plays a quite opposite role as tumor suppressor in others (Crawford et al, 2019; Li et al, 2019; Tong-Tong et al, 2019; Knudsen et al, 2020; Wang et al, 2021). This evidence concerns the gene EGR1 and cancer.