On the contrary, it was previously exhibited that EGR1 could form a complex with a Yes kinase-associated protein 1 (YAP1), thus regulating lipopolysaccharide-induced tissue factor expression in human endothelial cells or cell phenotypes of prostate cancer (Zagurovskaya et al, 2009; Yi et al, 2016). Here, YAP1 is linked to Familial prostate cancer.