The second group showed that the dominant anterior compartment muscles were involved, including childhood-onset RVM caused by MYH7 mutations; adult early-onset RVM variants in HSPB8, HNRNPA, and Desmin; and late-onset subtypes related to mutations in CRYAB, TTN, and VCP. Furthermore, the tibialis anterior muscle can be considered as a “red flag” indicating an MYH7-related myopathy (31). Here, DES is linked to myopathy.