Pathogenic changes in 13 genes associated with distal weakness (CLN3, ADSSL1, FHL1, DYSF, GNE, NOTCH2NLC, LRP12, and GIPC1) and proximal weakness (TCAP, FKRP, TRIM32, TTN, and GFPT1) cause an autosomal recessive (AR) form of RVM, and disease-causing variants in four genes (NOTCH2NLC, LRP12, GIPC1, and TTN) result in either AD or AR RVM. The gene discussed is DYSF; the disease is Alzheimer disease.