Currently, ~30 genes of distal weakness (MYH7, HSPB8, FLNC, BAG3, VCP, DESMIN, DNAJB6, HNRNPA1, ACTN2, ACTA1, NOTCH2NLC, LRP12, GIPC1, CRYAB, MYOT, ZASP, TIA1, TTN, MATR3, SQSTM1, SQSTM1/TIA1, and PLIN4) and proximal weakness (COL6A2, CACNA1S, TNPO3, D4Z4, SMCHD1, HNRNPDL, PABPN1, and CAV3) are associated with the autosomal dominant (AD) form of RVM. Here, LRP12 is linked to Alzheimer disease.