(38) reported that cathepsin C (CTSC), the protease produced by tumor cells, can activate proteinase 3 (PR3) on the neutrophil membrane, to promote interleukin-1β (IL-1β) to process and NF-κB to activate, which can upregulate interleukin-6 (IL-6) and CCL3, recruit neutrophils, and promote the production of ROS in neutrophils to induce NET formation. Here, PRTN3 is linked to neoplasm.