Moreover, in our study, increasing the GJB2 expression level, the lymph node stage gradually deteriorated (Figure 2C), which was consistent with the function of GJB2. Most of the current research, including several cancers, such as skin (22), prostate (23), and colorectal carcinoma (8), suggested the function of Cx26 or Cx43 being linked to enhancing the motility and aggressiveness of cancer cells. This evidence concerns the gene GJA1 and colorectal carcinoma.