Among them, several important LUAD-related pathways could be observed significantly enriched, including pathways in cancer (P<0.001), nod-like receptor signaling pathway (P<0.001), MAPK signaling pathway (P<0.001), apoptosis (P<0.001), P53 signaling pathway (P<0.001), JAK-STAT signaling pathway (P<0.001), TGF-Beta signaling pathway (P<0.001), WNT signaling pathway (P=0.003), non-small cell lung cancer pathway (P=0.023)(Figure 6A). Here, TP53 is linked to cancer.