In addition, the VAV1-STAP2 gene fusion protein, which is found in 8.2% of AITL patients without RHOA mutation, also induces Tyr174 hyperphosphorylation and promotes PLCγ1 phosphorylation even in the absence of TCR stimulation (14, 18). Here, RHOA is linked to angioimmunoblastic T-cell lymphoma.