Tall-cell PTC (OR = 5.96, 95% CI = 1.53–23.24, p = 0.01), angioinvasion (OR = 4.36, 95% CI = 1.73–10.95; p = 0.002), lymphatic invasion (OR = 4.03, 95% CI = 1.60–10.17; p = 0.003), extrathyroidal extension (OR = 9.17, 95% CI = 1.93–43.58; p = 0.005) and lymph node metastasis (OR = 4.03 95% CI = 1.60–10.17; p = 0.004) were dependent predictive factors of the NCOA4::RET rearrangement. This evidence concerns the gene NCOA4 and T-cell acute lymphoblastic leukemia.