In term of clinicopathological markers, the NCOA4::RET rearrangement was significantly associated with angioinvasion (p = 0.001), lymphatic invasion (p = 0.003), extrathyroidal extension (p = 0.001), lymph node metastasis (p < 0.001) and extranodal extension (p = 0.013), respectively. The gene discussed is NCOA4; the disease is metastasis.