VEGFA and inflammatory response: Despite various studies showing VEGF-A as an important molecular cue for lymphatic zippering (Zhang et al., 2018; Zhang et al., 2020; Churchill et al., 2022), the effects of VEGF-A in lymphatic junctional remodeling appear to be organ-specific, as VEGF-A signaling was not critical in remodeling of lymphatics after bacterial induced airway inflammation (Baluk et al., 2009), even though there is significant initial lymphatic vessel zippering (Yao et al., 2012).