While current research suggests that the regulation of lymphatic buttons and zippers are vital to lymphatic function, we do not know 1) how a single molecule Angpt2 can orchestrate both button and zipper formation throughout one continuous lymphatic vessel, 2) the molecular mechanisms determining LEC junctional conversion from buttons to zippers during inflammation, and 3) how junctional morphology and subsequent lymphatic function is altered in other inflammatory diseases such as atherosclerosis. Here, ANGPT2 is linked to atherosclerosis.