We observed a robust reduction in the proliferation of luminal breast cancer cells if hsa_circ_0086735 was individually inhibited, but increased again if both hsa_circ_0086735 and miR-1296-5p were inhibited until there was another reversal if hsa_circ_0086735, miR-1296-5p, and STAT1 were all inhibited (Figures 8C,D). The gene discussed is STAT1; the disease is breast carcinoma.