Recently, NEGR1 has been recognized as a risk factor for obesity (Willer et al., 2009) and diverse neurological disorders, including intellectual disabilities, schizophrenia, and major depression (Schizophrenia Working Group of the Psychiatric Genomics, 2014; Sniekers et al., 2017; Dall'Aglio et al., 2021). The gene discussed is NEGR1; the disease is obesity due to melanocortin 4 receptor deficiency.