Our data showed CHI leaves increased the levels of GR, GST, GPx, and TrxR enzymes activity as well as TrxR1 protein in the liver (Figures 1A–E) in healthy mice, TrxR and GPx enzymes activity in the liver and TrxR activity in serum (Figures 2F, G, 3F) in ALX-induced type 1 diabetic mice; and GPx, GST and TrxR enzymes activity in the liver (Figures 4H–J, 5K), as well as GST activity in serum (Figure 5J) in golden hamsters, fed a high-fat diet. Here, GSR is linked to type 1 diabetes mellitus.