Indeed, in this work, we found CHI leaves could quickly and markedly alleviate diabetic polyuria and polydipsia in a dose-dependent manner within 2 weeks post-treatment in diabetic mice (Figures 2A, B), and the mechanism involved in the enhanced renal water reabsorption associated protein UT-A1 and the increased trafficking of AQP2 to the apical plasma membrane (Figures 2H, I). This evidence concerns the gene AQP2 and diabetes mellitus.