(2) Exercise training could help improve cardiac apoptosis by decreasing the protein levels of t-Bid, Bad, Bak, Bax, caspase, and cytochrome-c (mitochondrial pathway) and lowering the protein levels of the Fas ligand, TNF, TNF receptor 1, and FADD (Fas pathway) in hypertension. This evidence concerns the gene BAX and hypertensive disorder.