Furthermore, the included studies reported that exercise training increased the levels of Bcl-2, Akt, p-Akt, PI3K, p-PI3K, IGF-1, and HSP 72 cardiac tissue in hypertension (16, 29, 32–35, 37), suggesting that exercise training increases the chances of cell survival in the cardiac tissue to counteract hypertension. Here, IGF1 is linked to hypertensive disorder.