BCL2 and hypertensive disorder: Furthermore, the included studies reported that exercise training increased the levels of Bcl-2, Akt, p-Akt, PI3K, p-PI3K, IGF-1, and HSP 72 cardiac tissue in hypertension (16, 29, 32–35, 37), suggesting that exercise training increases the chances of cell survival in the cardiac tissue to counteract hypertension.