The results showed that RA was positively correlated with coronary atherosclerosis (OR: 1.0015, 95%CI 1.0004–1.0026, P < 0.05), and IL-6 was negatively correlated with coronary atherosclerosis (OR: 0.9911, 95%CI 0.9855–0.9967, P < 0.05), but the number of SNPS included was less. The gene discussed is IL6; the disease is coronary atherosclerosis.