Foxp3+CXCR5+ cTfr cells were increased in SS patients, especially in autoantibody-positive SS patients (71, 77), while another study reported that the percentages of CXCR5+Foxp3+CD25+ cTfr cells and the ratio of Tfr/Tfh were decreased in SS patients (78). The gene discussed is TFRC; the disease is synovial sarcoma.