Increasing studies have reported that the neuroinflammation caused by microglia in the striatum mediates various central diseases, such as Parkinson’s disease (37), schizophrenia (38), Alzheimer’s disease (39, 40), and other negative affective conditions (41); and the potential molecular mechanisms include IL-13 (42), IL-6 (41), TREM2 (39), BIN1 (39), and toll-like receptors (36). This evidence concerns the gene BIN1 and early-onset autosomal dominant Alzheimer disease.