Comparison of the abundance of each cell type between 8 paired tumor and normal samples revealed that the tumor tissue had significantly higher proportions of CD8 Tex, Tregs, and TREM2+ TAMs (Figure 1G), suggesting that TREM2+ TAMs were related to increased CD8 Tex and contributed to an immunosuppressive TME, consistent with observations in mouse tumor models (18). Here, CD8A is linked to neoplasm.