In studies performed in mice with genetic deletion of Adora2b, when murine PDAC cell lines derived from Pdx1:Cre; LsL-KrasG12D;LsL-Trp53R172H/+ (KPC) mice, were implanted subcutaneously, tumor growth was significantly reduced compared to implanted cells in WT mice and there was a significant increase in Granzyme B (GZM+) and CD8+ T cells in KPC-derived tumors implanted in Adora2b-/- mice (4). The gene discussed is ADORA2B; the disease is neoplasm.