HIF1A and acute pancreatitis: In a mouse model of caerulean-induced acute pancreatitis, injured tissues presented high expression of HIF-1α, and inhibition of HIF-1α, through intraperitoneal injections of HIF-1α small molecule inhibitor PX478, reduced RIP3/p-MLKL expression and ROS production, mitigating acinar cell injury and necrosis (25).