HSPD1 and rheumatoid arthritis: Some studies describe that HSP60 disturbs the effector functions of neutrophils, i.e. HSP60 enhances the phagocytic activity of neutrophils (84); bacterial HSP GroEL from Staphylococcus epidermidis biofilms promoted ADN decondensation and induced NETosis (85); inflammatory cytokines can lead to NETosis in neutrophils from RA patients (86).