Here, we found that the immune signature of a primary HCMV infection in LTRs is associated with a significant increase in total circulating CD8 T, δ2negγδT cell frequency and the emergence of pp65- and UL40-specific CD8 T cells and adaptive NKG2C+CD57+ NK cells consistent with previous studies (13, 14, 29–31). Here, KLRC2 is linked to cytomegalovirus infection.