However, Trms subsets in lung cancer exhibit distinct expression patterns that can be divided into three CD8 clusters: GZMK+CD8+ (high-level PDCD1, low-level ITGAE), ZNF683+CD8+ (low-level PDCD1, high-level ITGAE), and LAYN+CD8+ (high-level PDCD1 and high-level ITGAE) (14). This evidence concerns the gene PDCD1 and lung carcinoma.