Similarly, another study also identified two types of tumor ECs: INSR+ tumor EC (INSRhiHSPG2+PLVAP+) and ACKR1+ tumor EC (ACKR1+SELP+IL1R1+) in early-stage lung cancer that radiologically manifests as part-solid nodules (31). The gene discussed is ACKR1; the disease is neoplasm.