Also, we did not observe (ii) a spatial co-localization of CD271+ tumor cells with PD-L1 which would have been expected given previous observations from human triple-negative breast cancer and lung adenocarcinoma describing a strong correlation between tumor stemness and PD-L1 expression (66–68) and (iii) no impact on patient neither on response to RCTx or patient prognosis. This evidence concerns the gene CD274 and lung adenocarcinoma.