CD274 and neoplasm: The observation that patients who presented with a strong intratumoral PD-L1 expression and CTL-infiltration within the tumor cell compartment achieved better survival outcomes demonstrates that PD-L1 expression cannot be interpreted solely as a marker of immune evasion in the context of OPSCC but might rather reflect a response to activation of an endogenous inflammatory immune reaction at the tumor site (4, 60).