Using univariable Cox proportional hazard models with continuous predictors (non-thresholded) the abundance of tumor-infiltrating CD8 T cells did however significantly correlate with PFS (HR: 0.99, 95% CI: 0.98-1.0, p=0.026) and OS (HR: 0.98, 95% CI: 0.97-1.0, p=0.01) in the p16-negative patient cohort, while this did not apply for the overall CD8 infiltration. The gene discussed is CDKN2A; the disease is neoplasm.