Acute respiratory distress syndrome (ARDS) is brought on by the pathogenic human COVID, which attaches to its target cells via angiotensin-converting enzyme 2 (ACE2) receptors. ACE2 is the primary hormone of the renin-angiotensin-aldosterone system (RAAS). The task of this system is to maintain water and sodium, as well as vascular resistance and thus blood pressure (BP) [6,9]. ACE2 exists in the bronchial epithelium, vascular endothelium, alveolar cells, kidney, and intestine [9,18]. This evidence concerns the gene REN and acute respiratory distress syndrome.